متوترکسات در درمان آرتریت روماتوئید جوانان

author

  • شفائی, ناهید
Abstract:

Juvenile Chronic Arthritis (JCA) and Juvenile Rheumatoid Arthritis (JRA) are a group of heterogenous idiopathic arthritis with an unclear pathogenesis, most probably, autoimmune phenomenon. The goals of chemotherapy in JRA are to suppress chronic synovitis, to control the systemic effects of the disease on growth and developement of the patients and, ideally, to make young patients lead a normal life. MTX. has proved to be the most effective drug in this therapeutic measures of these patients, but the side effects of the drug are potentially serious and the most important cause for concern the tratment of chi/ren and young adults. Although the mechanism of action of MTX is not fully known, it is said to modify the cytokine synthesis, and with the low dose, increase the adenosine release. In this article we have reviewed the effect of MTX on JCA and JRA during the past 10 years. The results show wide use of MTX. on pediatr c rheumatology patients. For the best results the drug should be used within two years after the diagnosis. The therapy should conform to the protocol of the Pediatric Rhematology Collaborative Study Group (PRCSG). The suggested dose is 10 mg/m2/ week orally. Although the side effects are potentially serious, the use of this drug, under certain considerations is acceptable. Folic acid may decrease some of the side effects. Dehydration, for any reason, and the use of cotrimoxazole should be avoided. When the disease comes under control, the drug can be prescribed every other week.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

مقایسه درمان تک دارویی و چند دارویی در آرتریت روماتوئید

Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition. The condition can affected many tissues throught out the body, but the joints are usually most severely affected. The high incidence of RA, the conventional treatments and the experimental observation have shown by combination therapy, the disease symptoms of the patients reduce. To compare the efficacy and tolerabi...

full text

بررسی عوارض سدیم تیومالات طلا در درمان آرتریت روماتوئید

To determine the complications of gold sodium thiomalate therapy in rheumatoid arthritis (RA), 32 patients with active RA (27 female, 5 male) treated for a mean period of 28 ? 14 weeks were studied. From these patients, 62.5 (46-79) percent showed at least one drug reaction. Pruritus was the most common complication occurred in 59 (42-76) percents, and was accompanied by skin rush in 37 (15-57)...

full text

استئومالاسی در روماتوئید آرتریت

    Background & Aims : Osteomalacia and biochemical evidence of vitamin-D deficiency may in some cases contribute to the pathogenesis of osteopenia and increase the risk of spontaneous fracture formation in rheumatoid arthritis (RA).   Materials & Methods : A consecutive series of 93 patients diagnosed with RA who were admitted to the Internal Medicine Department of Ghem Medical Center in Mash...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue 1

pages  18- 25

publication date 1998-12

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023